منابع مشابه
NEAT HFpEF: Organic nitrates fail to deliver
Received: 8 November 2015 Accepted: 29 January 2016 c © 2016 The Author(s), licensee Magdi Yacoub Institute. This is an open access article distributed under the terms of the Creative Commons Attribution license CC BY-4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. Cite this article as: Wagdy K, Hassan M. NEAT HFpEF...
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Nitric oxide (NO) is one of the most important vasodilator molecules produced by the endothelium. It has already been established that NO/cGMP signaling pathway deficiencies are involved in the pathophysiological mechanisms of many cardiovascular diseases. In this context, the development of NO-releasing drugs for therapeutic use appears to be an effective alternative to replace the deficient e...
متن کاملDo we still need organic nitrates?
rganic nitrates are still quite frequently used for the reatment of acute and chronic angina, and acute and hronic congestive heart failure. When given acutely, their ffectiveness is undisputable; however, their long-term effiacy is substantially limited due to the development of olerance (1) and the induction of endothelial dysfunction (2), parameter that has prognostic significance in patient...
متن کاملStereoselective pharmacokinetics and pharmacodynamics of organic nitrates in rats.
Plasma concentration and vasodilating effect after i.v. bolus injection of stereoisomeric organic nitrates were evaluated. Pharmacokinetics of mononitrates was analyzed with a linear one-compartment model. The apparent volumes of distribution were almost identical, but systemic clearances were different among stereoisomers. The concentration data after dinitrate administration could be describe...
متن کاملKnowledge, Attitude and Practice of Physicians in Appropriate Prescription of Organic Nitrates in Iran
Organic nitrates are commonly used in angina pectoris and ischemic cardiomyopathy. In order to optimize their effectiveness and patient convenience, several aspects must be observed. Adequate doses, suitable dosage forms and asymmetric pattern of usage to prevent the nitrate tolerance are some factors that a physician must be familiar with. The objective of the present study was to define the p...
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ژورنال
عنوان ژورنال: Heart - Lung (Varna)
سال: 2013
ISSN: 1310-6341
DOI: 10.14748/hl.v19i1-2.3352